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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of study design, including the recruitment and consent process, 프라그마틱 슬롯 as well as adherence and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from different geographical regions. This type of heterogeneity is required for practical trials to be valid and helps to reduce bias in the results. Too much heterogeneity, however could cause issues with the trial design.

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The purpose of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. They are typically commissioned by policymakers and practitioners in order to guide their decisions. They also provide a useful way to identify the causality between the intervention and its effects. They should, however, not, be used to replace explanatory studies.

The pragmatism concept is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.

There is a growing increase in the number pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.